Chronic toluene exposure and the hippocampal structure in adolescent and adult brains (review)

Zhvania, Mzia G and Japaridze, Nadezhda and Chilachava, Lela R and Fochkhidze , Nino (2015) Chronic toluene exposure and the hippocampal structure in adolescent and adult brains (review). In: Neurobiology of drug addiction and Substance Abuse. Elsevier, London, King College. (In Press)

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Abstract

Toluene and toluene containing volatile substances are the most commonly abused solvents with a demonstrative addictive potential for humans. The misuse of these substances is associated with the activation of brain areas involved in both addiction and learning. As potential substrates for both processes, the regions of the mesocorticolimbic system have been identified. A number of clinical and experimental studies indicate that the hippocampus is involved in toluene addiction. In particular, toluene affects learning and memory and provokes various molecular, biochemical and structural alterations in the hippocampus of adolescents and adults. The character of these alterations depends upon the age the organism tested. In the present chapter we review immediate and persistent effects of chronic toluene exposure on the structure of the hippocampus in organisms of different ages.

Item Type: Book Section
Subjects: Q Science > QF Neurobiology
Q Science > QB Astronomy
Depositing User: Professor Mzia (Ia) G Zhvania
Date Deposited: 29 Jun 2015 09:41
Last Modified: 29 Jun 2015 09:41
URI: http://eprints.iliauni.edu.ge/id/eprint/2981

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