Shrestha, BR და Vitolo, OV და Joshi, P და Lordkipanidze, Tamar (2006) Amyloid beta peptide adversely affects spine number and motility in hippocampal neurons. Mol Cell Neurosci, 33 (3). С. 274-282.
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Elevated levels of amyloid-beta peptide (Abeta) are found in Down's syndrome patients and alter synaptic function during the early stages of Alzheimer's disease. Dendritic spines, sites of most excitatory synaptic contacts, are considered to be an important locus for encoding synaptic plasticity. We used time-lapse two-photon imaging of hippocampal pyramidal neurons in organotypic slices to study the effects of Abeta on the development of dendritic spines. We report that exposure of hippocampal neurons to sub-lethal levels of Abeta decreased spine density, increased spine length and subdued spine motility. The effect of Abeta on spine density was reversible. Moreover, Abeta's effect on dendritic spine density was blocked by rolipram, a phosphodiesterase type IV inhibitor, suggesting the involvement of a cAMP dependent pathway. These findings raise the possibility that Abeta-induced spine alterations could underlie the cognitive defects in Alzheimer's disease and Down syndrome.
| ობიექტის ტიპი: | სტატია |
|---|---|
| თემატიკა: | Q Science > Q Science (General) |
| ქვეგანყოფილება: | Institutes > Institute of Chemical Biology |
| განმათავსებელი მომხმარებელი: | Professor Tamar Lordkipanidze |
| განთავსების თარიღი: | 01 ივნისი 2015 05:51 |
| ბოლო ცვლილება: | 01 ივნისი 2015 05:51 |
| URI: | http://eprints.iliauni.edu.ge/id/eprint/2835 |
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Amyloid beta peptide adversely affects spine number and motility in hippocampal neurons. (deposited 22 იანვარი 2014 14:35)
- Amyloid beta peptide adversely affects spine number and motility in hippocampal neurons. (deposited 01 ივნისი 2015 05:51) [ასახულია მიმდინარე დროს]
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