Amyloid beta peptide adversely affects spine number and motility in hippocampal neurons.

Shrestha, BR და Vitolo, OV და Joshi, P და Lortdkipanidze, Tamar (2006) Amyloid beta peptide adversely affects spine number and motility in hippocampal neurons. Mol Cell Neurosci, 33 (3). С. 274-282.

სრული ტექსტი ამ საცავიდან ხელმიუწვდომელია.
ოფიციალური URL: http://www.ncbi.nlm.nih.gov/pubmed/16962789

რეზიუმე

Elevated levels of amyloid-beta peptide (Abeta) are found in Down's syndrome patients and alter synaptic function during the early stages of Alzheimer's disease. Dendritic spines, sites of most excitatory synaptic contacts, are considered to be an important locus for encoding synaptic plasticity. We used time-lapse two-photon imaging of hippocampal pyramidal neurons in organotypic slices to study the effects of Abeta on the development of dendritic spines. We report that exposure of hippocampal neurons to sub-lethal levels of Abeta decreased spine density, increased spine length and subdued spine motility. The effect of Abeta on spine density was reversible. Moreover, Abeta's effect on dendritic spine density was blocked by rolipram, a phosphodiesterase type IV inhibitor, suggesting the involvement of a cAMP dependent pathway. These findings raise the possibility that Abeta-induced spine alterations could underlie the cognitive defects in Alzheimer's disease and Down syndrome.

ობიექტის ტიპი: სტატია
თემატიკა: Q Science > Q Science (General)
ქვეგანყოფილება: Institutes > Institute of Chemical Biology
განმათავსებელი მომხმარებელი: Professor Tamar Lordkipanidze
განთავსების თარიღი: 22 იანვარი 2014 14:35
ბოლო ცვლილება: 07 თებერვალი 2014 22:09
URI: http://eprints.iliauni.edu.ge/id/eprint/416

ამ მასალაზე ხელმისაწვდომი ვერსია

Actions (login required)

ობიექტის ნახვა ობიექტის ნახვა