Amyloid beta peptide adversely affects spine number and motility in hippocampal neurons.

Shrestha, BR and Vitolo, OV and Joshi, P and Lordkipanidze, Tamar (2006) Amyloid beta peptide adversely affects spine number and motility in hippocampal neurons. Mol Cell Neurosci, 33 (3). pp. 274-282.

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Abstract

Elevated levels of amyloid-beta peptide (Abeta) are found in Down's syndrome patients and alter synaptic function during the early stages of Alzheimer's disease. Dendritic spines, sites of most excitatory synaptic contacts, are considered to be an important locus for encoding synaptic plasticity. We used time-lapse two-photon imaging of hippocampal pyramidal neurons in organotypic slices to study the effects of Abeta on the development of dendritic spines. We report that exposure of hippocampal neurons to sub-lethal levels of Abeta decreased spine density, increased spine length and subdued spine motility. The effect of Abeta on spine density was reversible. Moreover, Abeta's effect on dendritic spine density was blocked by rolipram, a phosphodiesterase type IV inhibitor, suggesting the involvement of a cAMP dependent pathway. These findings raise the possibility that Abeta-induced spine alterations could underlie the cognitive defects in Alzheimer's disease and Down syndrome.

Item Type:	Article
Subjects:	Q Science > Q Science (General)
Divisions:	Institutes > Institute of Chemical Biology
Depositing User:	Professor Tamar Lordkipanidze
Date Deposited:	01 Jun 2015 05:51
Last Modified:	01 Jun 2015 05:51
URI:	http://eprints.iliauni.edu.ge/id/eprint/2835

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• Amyloid beta peptide adversely affects spine number and motility in hippocampal neurons. (deposited 22 Jan 2014 14:35)
  • Amyloid beta peptide adversely affects spine number and motility in hippocampal neurons. (deposited 01 Jun 2015 05:51) [Currently Displayed]

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