The beta-lactam Clavulanic Acid without Antibacterial Activity Mediates Glutamate Transport-sensitive Pain-relief in the Chronic Constriction Injury Rat Model of Neuropathic Pain

Gegelashvili, Georgi (2017) The beta-lactam Clavulanic Acid without Antibacterial Activity Mediates Glutamate Transport-sensitive Pain-relief in the Chronic Constriction Injury Rat Model of Neuropathic Pain. FIP-PSWC 2017 Congress Publications, 1. pp. 1-3.

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Abstract

For the first time it is demonstrated that clavulanic acid (CA), in chronic dosing, could mitigate neuropathic pain and up-regulate GluTs, including GLT1b isoform, both in vivo and in vitro, also in human cells. The study sets the perspectives for developing new beta-lactam-based analgesics, devoid of antibacterial activity, for treatment of chronic pain.

Item Type: Article
Uncontrolled Keywords: Chronic Pain; Beta-lactams; Clavulanic Acid; CCI model; Human astrocytes; Analgesia; Drug design; Glutamate transporters; GLT1b; GLAST; Ceftriaxone; Spinal cord;
Subjects: Q Science > QY Biophysics
Q Science > Molecular Biosciences
Q Science > QF Neurobiology
Q Science > QP Physiology
Q Science > QR Microbiology
R Medicine > RM Therapeutics. Pharmacology
Divisions: Faculties/Schools > School of Natural Sciences and Engineering
Depositing User: პროფესორი გიორგი (გოგი) გეგელაშვილი
Date Deposited: 19 Apr 2018 09:46
Last Modified: 19 Apr 2018 09:46
URI: http://eprints.iliauni.edu.ge/id/eprint/7928

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