A Critical Evaluation of the Methodological Obstacles to Translating Cell-Based Research Into an Effective Treatment for People With Parkinson’s Disease

Karimi, Leila and Polgar, Stephen and Buultjens, Melissa and Morris , Meg E. (2016) A Critical Evaluation of the Methodological Obstacles to Translating Cell-Based Research Into an Effective Treatment for People With Parkinson’s Disease. Neurorehabilitation and Neural Repair. pp. 1-9. ISSN 1552-6844

Text 1545968316635277.abstract - Published Version Download (65kB)

Abstract

The remarkable scientific and technological advances in the field of cell research have not been translated into viable restorative therapies for brain disorders. In this article, we examine the best available evidence for the clinical efficacy of reconstructive intracerebral transplantation in people with Parkinson’s disease (PD), with the aim of identifying methodological obstacles to the translation process. The major stumbling block is the fact that the potential contributions of people with neural grafts and the effects of the physical and social environment in which they recover have not been adequately investigated and applied to advancing the clinical stages of the research program. We suggest that the biopsychosocial model along with emerging evidence of targeted rehabilitation can provide a useful framework for conducting research and evaluation that will ensure the best possible outcomes following intracerebral transplantation for PD.

Item Type:	Article
Uncontrolled Keywords:	biopsychosocial approach, methodology, rehabilitation, intracerebral transplantation, Parkinson’s disease, patient-centered practice
Subjects:	H Social Sciences > HL Healthcare Policy and Management H Social Sciences > HO Public Health
Divisions:	Centres > Insurance and Public Health Center
Depositing User:	Professor Tengiz Verulava
Date Deposited:	09 Mar 2016 06:30
Last Modified:	09 Mar 2016 06:30
URI:	http://eprints.iliauni.edu.ge/id/eprint/4062

Actions (login required)

View Item