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Zhvania, Mzia G and Japaridze, N.J. and Ksovreli, M and Kiladze, Maia and Okuneva, VG and Surmava, AG and Lordkipanidze, Tamar and Kotaria, Nato (2012) Effect of chronic hypokinetic stress on the structure of axo-dendritic synapses in the central nucleus of the amygdala of the rat: an electron microscopic investigation. Journal of Biological Physics and Chemistry, 12 (4). pp. 148-152. ISSN ISSN 1512-0856
Full text not available from this repository.Abstract
The effect of 90 days of hypokinetic stress on the ultrastructure of axo-dendritic synapses and porosomes in the rat central nucleus of the amygdala was investigated. In some presynaptic terminals significant pathological alterations, such as agglutination of synaptic vesicles, occurrence of vacuoles, osmiophilic and membrane-like bodies or the destruction of presynaptic mitochondria, were revealed. Furthermore, an increase in the number of synaptic preterminals with granular and/or single synaptic vesicles or modifications in the osmiophilicity of synaptic contacts and/or types of spines were observed. In such synapses pathological or some other modifications in synaptic plasticity or in the transmission process may take place. There were no alterations in the main structural parameters (diameter and depth) of the porosome.
| Item Type: | Article |
|---|---|
| Subjects: | Q Science > QD Chemistry |
| Divisions: | Institutes > Institute of Chemical Biology |
| Depositing User: | Professor Mzia (Ia) G Zhvania |
| Date Deposited: | 22 Jan 2014 14:34 |
| Last Modified: | 07 Feb 2014 22:11 |
| URI: | http://eprints.iliauni.edu.ge/id/eprint/405 |
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