Moesin-dependent cytoskeleton remodelling is associated with an anaplastic phenotype of pancreatic cancer.

Abiatari, Ivane და Esposito, Irene და Oliveira, Tiago De და Felix, Klaus და Xin, Hong და Penzel, Roland და Giese, Thomas და Friess, Helmut და Kleeff, Jörg (2010) Moesin-dependent cytoskeleton remodelling is associated with an anaplastic phenotype of pancreatic cancer. Journal of cellular and molecular medicine, 14 (5). С. 1166-79. ISSN 1582-4934

ტექსტი Abiatari et al_moesin dependent cytoskeleton remodelling is associated with an anaplastic phenotype of pancreatic cancer.pdf Download (2MB)

რეზიუმე

Cell motility is controlled by the dynamic cytoskeleton and its related proteins, such as members of the ezrin/radixin/moesin (ERM) family, which act as signalling molecules inducing cytoskeleton remodelling. Although ERM proteins have been identified as important factors in various malignancies, functional redundancy between these proteins has hindered the dissection of their individual contribution. The aim of the present study was to analyse the functional role of moesin in pancreatic malignancies. Cancer cells of different malignant lesions of human and transgenic mice pancreata were evaluated by immunohistochemistry. For functional analysis, cell growth, adhesion and invasion assays were carried out after transient and stable knock-down of moesin expression in pancreatic cancer cells. In vivo tumourigenicity was determined using orthotopic and metastatic mouse tumour models. We now show that moesin knock-down increases migration, invasion and metastasis and influences extracellular matrix organization of pancreatic cancer. Moesin-regulated migratory activities of pancreatic cancer cells were in part promoted through cellular translocation of beta-catenin, and re-distribution and organization of the cytoskeleton. Analysis of human and different transgenic mouse pancreatic cancers demonstrated that moesin is a phenotypic marker for anaplastic carcinoma, suggesting that this ERM protein plays a specific role in pancreatic carcinogenesis.

ობიექტის ტიპი:	სტატია
თემატიკა:	R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
განმათავსებელი მომხმარებელი:	Dr Ivane Abiatari
განთავსების თარიღი:	30 აპრილი 2015 05:28
ბოლო ცვლილება:	30 აპრილი 2015 05:28
URI:	http://eprints.iliauni.edu.ge/id/eprint/2215

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