Collagen photodegradation under UV irradiation

Metreveli, N and Namicheishvili, L and Jariashvili, K and Chikvaidze , E and Mrevlishvili , G (2005) Collagen photodegradation under UV irradiation. Journal of Biological Physics and Chemistry, 5 (4). pp. 133-136. ISSN 1512-0856

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The influence of UV irradiation on the collagen triple helix has been studied at the molecular level. It is shown that UV irradiation causes the appearance of primer free radicals in the water surrounding the collagen, which then interact with the proline residue of the protein with the appearance of secondary free radicals. This is connected with destabilization of the collagen molecule as the defects in the amino acid residues probably lead to cleavage of the covalent bonds near the damaged sites, so maintaining the triple helical structure. The presence of ascorbic acid (vitamin C) in the solution protects the collagen molecule from the action of the secondary free radicals.

Item Type: Article
Subjects: Q Science > QC Physics
Q Science > QH Natural history > QH301 Biology
Divisions: Institutes > Institute of Biophysics
Depositing User: პროფესორი ნუნუ მეტრეველი
Date Deposited: 18 Feb 2014 06:19
Last Modified: 18 Feb 2014 06:19

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