Effects of phencyclidines on signal transfer from the entorhinal cortex to the hippocampus in rats.

Dugladze, Tamar and Lepsveridze, Eka and Breustedt, J. and Kehrer, C. and Heineman, Uwe and Gloveli, Tengiz (2004) Effects of phencyclidines on signal transfer from the entorhinal cortex to the hippocampus in rats. Neurosci Lett. , 354 (3). pp. 185-188.

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Abstract

The information transfer from the superficial layers of the entorhinal cortex (EC) to the hippocampus is regulated in a frequency dependent manner. Phencyclidine and related compounds such as MK-801 produce psychotic symptoms that closely resemble schizophrenia. We studied the effects of systemic administration of MK-801 on the signal transfer from the EC layer III to the hippocampal area CA1. High frequency (above 10 Hz) activation of the bi-synaptic entorhinal input in control animals results in a strong suppression of the field potentials in the stratum lacunosum-moleculare of the area CA1. In contrast, in MK-801 pretreated rats the field response was less reduced. The field potential responses evoked in these two groups of animals by high-frequency activation of the monosynaptic input were similar suggesting selective alterations in layer III of the medial EC. We suggest, that MK-801 causes disinhibition of layer III projection cells and, therefore, may cause strong, pathological activation of direct layer III-CA1 pathway.

Item Type: Article
Subjects: Q Science > QP Physiology
Divisions: Faculties/Schools > Faculty of Arts and Sciences
Depositing User: Dr. Eka Lepsveridze
Date Deposited: 07 Apr 2015 08:52
Last Modified: 07 Apr 2015 08:52
URI: http://eprints.iliauni.edu.ge/id/eprint/253

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