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Effect of Myo-inositol treatment on hippocampal cell loss triggered by kainic acid induced status epilepticus: light and electron microscope studies

Kotaria, Nato and Zhvania, Mzia G and Kiladze, Maia and Japaridze, Nadezhda and Solomonia, Revaz and Bikashvili, Tamar and Bolkvadze, Tamar (2013) Effect of Myo-inositol treatment on hippocampal cell loss triggered by kainic acid induced status epilepticus: light and electron microscope studies. Cellular and Molecular Neurobiology, 33 (5). pp. 659-671. ISSN 0272-4340

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Abstract

Recently it was shown that myo-inositol pretreatment attenuates the seizure severity and several biochemical changes provoked by experimentally induced status epilepticus. However it remains unknown whether such properties of myo-inositol influence the structure of epileptic brain. In the present light and electron microscopic research we elucidate if pretreatment with myo-inositol has positive effect on hippocampal cell loss and cell damage provoked by kainic acid induced status epilepticus. Adult male Wistar rats were treated with (i) saline, (ii) saline + kainic acid, (iii) myo-inositol + kainic acid. The cell loss was assessed 2, 14 and 30 days after treatment in radial, oriental and pyramidal cell layers of CA1 and CA3. The ultrastructural alterations were described in CA1, 14 days after treatment. The cytoprotective effect of myo-inositol was shown. Itt was most strongly expressed in pyramidal layer of CA1 and radial and oriental layers of CA3, in less degree - in almost all other layers of both areas. Electron-microscopic studies also indicate that in comparing with rats treated with kainic acid, the ultrastructure of CA1 of animals pretreated with myo-inostiol is more preserved. Such data give us the possibility to share recent opinion that in addition to other functions, myo-inositol possesses antiepileptogenic properties.

Item Type: Article
Subjects: Q Science > QP Physiology
Divisions: Institutes > Institute of Chemical Biology
Depositing User: Professor Mzia (Ia) G Zhvania
Date Deposited: 20 Jan 2014 08:45
Last Modified: 30 Jun 2016 12:22
URI: http://eprints.iliauni.edu.ge/id/eprint/225

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