Kotaria, Nato და Zhvania, Mzia G და Kiladze, Maia და Japaridze, Nadezhda და Solomonia, Revaz და Bikashvili, Tamar და Bolkvadze, Tamar (2013) Effect of Myo-inositol treatment on hippocampal cell loss triggered by kainic acid induced status epilepticus: light and electron microscope studies. Cellular and Molecular Neurobiology, 33 (5). С. 659-671. ISSN 0272-4340
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ტექსტი
CEMN-S-13-00028.pdf Download (2MB) | გადახედვა |
რეზიუმე
Recently it was shown that myo-inositol pretreatment attenuates the seizure severity and several biochemical changes provoked by experimentally induced status epilepticus. However it remains unknown whether such properties of myo-inositol influence the structure of epileptic brain. In the present light and electron microscopic research we elucidate if pretreatment with myo-inositol has positive effect on hippocampal cell loss and cell damage provoked by kainic acid induced status epilepticus. Adult male Wistar rats were treated with (i) saline, (ii) saline + kainic acid, (iii) myo-inositol + kainic acid. The cell loss was assessed 2, 14 and 30 days after treatment in radial, oriental and pyramidal cell layers of CA1 and CA3. The ultrastructural alterations were described in CA1, 14 days after treatment. The cytoprotective effect of myo-inositol was shown. Itt was most strongly expressed in pyramidal layer of CA1 and radial and oriental layers of CA3, in less degree - in almost all other layers of both areas. Electron-microscopic studies also indicate that in comparing with rats treated with kainic acid, the ultrastructure of CA1 of animals pretreated with myo-inostiol is more preserved. Such data give us the possibility to share recent opinion that in addition to other functions, myo-inositol possesses antiepileptogenic properties.
| ობიექტის ტიპი: | სტატია |
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| თემატიკა: | Q Science > QP Physiology |
| ქვეგანყოფილება: | Institutes > Institute of Chemical Biology |
| განმათავსებელი მომხმარებელი: | Professor Mzia (Ia) G Zhvania |
| განთავსების თარიღი: | 20 იანვარი 2014 08:45 |
| ბოლო ცვლილება: | 30 ივნისი 2016 12:22 |
| URI: | http://eprints.iliauni.edu.ge/id/eprint/225 |
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