Javakheti Highland is one of the most seismic active regions of the Caucasus. The majority of earthquakes observed throughout the region occur within this small area (f = 40.8° - 41.8° ; l = 43.3° - 44.3°). One can expect that exclusive seismic activity of Javakheti Highland testifies to global geophysical processes which take place throughout the Caucasus region. Based on the above-mentioned, of interest was to study variation with time of the number of earthquakes occurring in Javakheti region. We analysed some 695 relatively small earthquakes (2.5 < M < 6.0) observed in Javalkheti Highland within the period of 1961-1992 with regard to large earthquakes M > 6.0 of the region which occurred in the same period. It was found that each large earthquake of the Caucasus is anticipated by clear precursor in a form of an anomalous change in the number of relatively small earthquakes in Javakheti Highland.