1. Air Quality Guidelines, 2nd edn. Copenhagen: World Health Organization Regional Office for Europe (2000). 2. Byrne, A., Kirby, B., Zibin, T. and Ensminger, S. Psychiatric and neurological effects of chronic solvent abuse. Can. J. Psychiatry 36 (1991) 735–738. 3. Mueser, K.T., Yarnold, P.R., Levinson, D.F., Singh, H., Bellack, A.S., Kee, K., Morrison, R.L. and Yadalam, K.G. Prevalence of substance abuse in schizophrenia: demographic and clinical correlates. Schizophrenia Bull. 16 (1990) 31–56. 4. Greenberg, M.M. The central nervous system and exposure to toluene: a risk characterization. Environ. Res. 71 (1997) 1–7. 5. Ikeuchi, Y., Hirai, H., Okada, Y., Mio, T. and Matsuda, T. Excitatory and inhibitory effects of toluene on neural activity in guinea pig hippocampal slices. Neurosci. Lett. 158 (1993) 63–66. 6. Stengard, K. Tail pinch increases acetylcholine release in rat striatum even after toluene exposure. Pharmacol. Biochem. Behav. 52 (1995) 261–264. 7. Urban, P. and Lukaš, E. The significance of neurophysiological methods in neurotoxicology. Clin. Neurophysiol. 112 (2001) 1139–1145. 8. Ghosh, T.K., Copeland, R.L. and Pradhan, S.N. Sensitivity of EEG in young rats to toluene exposure. Pharmacol. Biochem. Behav. 36 (1990) 779–785. 9. Oniani, T.N. Integrative Function of the Limbic System. Tbilisi: Metsniereba (1980). 10. Cruz, S.L., Mirshahi, T., Thomas, B., Balster, R.L. and Woodward, J.J. Effects of the abused solvent toluene on recombinant N-methyl-D-aspartate and non-N-methyl-Daspartate receptors expressed in Xenopus oocytes. J. Pharmacol. Exp. Ther. 286 (1998) 334–340. 11. Chen, H.H, Wei, C.T., Lin, Y.R., Chien, T.H. and Chan, M.H. Neonatal toluene exposure alters agonist and antagonist sensitivity and NR2B subunit expression of NMDA receptors in cultured cerebellar granule neurons. Toxicol. Sci. 85 (2005) 666–674. 12. Mattia, C.J., Ali, S.F. and Bondy, S.C. Toluene-induced oxidative stress in several brain regions and other organs. Mol. Chem. Neuropathol. 18 (1993) 313–328. 13. Prospero-Garcia, O., Criado, J.R. and Henriksen, S.J. Pharmacology of ethanol and glutamate antagonists on rodent sleep: a comparative study. Pharmacol. Biochem. Behav. 49 (1994) 413–416. 14. Tamimi, R.M, Lagiou, P., Adami, H.O., Trichopoulos, D. Prospects for chemoprevention of cancer. J. Int. Med. 251 (2002) 286–300. 15. Bouayed, J., Rammal, H., Dicko, A., Younos, C. and Soulimani, R. Chlorogenic acid, a polyphenol from Prunus domestica (mirabelle), with coupled anxiolytic and antioxidant effects. J. Neurol. Sci. 262 (2007) 77–84. 16. Shinomiya, K., Omichi, J., Ohnishi, R., Ito, H., Yoshida, T. and Kamei, C. Effects of chlorogenic acid and its metabolites on the sleep–wakefulness cycle in rats. Eur. J. Pharmacol. 504 (2004) 185–189. 17. Lapchak, P.A. The phenylpropanoid micronutrient chlorogenic acid improves clinical rating scores in rabbits following multiple infarct ischemic strokes: synergism with tissue plasminogen activator. Exp. Neurol. 205 (2007) 407–413. 18. Valko, M., Leibfritz, D., Moncol, J., Cronin, M.T., Mazur, M. and Telser, J. Free radicals and antioxidants in normal physiological functions and human disease. Int. J. Biochem. Cell Biol. 39 (2007) 44–84. 19. Beradze, G., Shanshiashvili, L. and Mikeladze, D. The alteration of sleep–wakefulness phases can be induced by quantitative changes in excitatory amino acids. Neurobiol. Sleep–Wakefulness Cycle 1 (2001) 40–43. 20. Maddocks, S. and Setchell, B.P. Testosterone concentrations in testicular interstitial fluid collected with a push-pull cannula or by drip-collection from adult rats given testosterone or aminoglutethimide. J. Endocrinol. 121 (1989) 303–309. 21. Paxinos, G. and Watson, C. The Rat Brain Stereotaxic Coordinates. Sidney: Academic Press (1997). 22. Saavedra, H., De Marinis, A. and Palestini, M. Neuronal changes induced by chronic toluene exposure in the cat. Arch. Ital. Biol. 134 (1996) 217–225. 23. Castilla-Serna, I., Barragan-Mejia, M.G., Rodriguez-Perez, R.A., Garcia-Rillo, A. and Reyes-Vazquez, C. Effects of acute and chronic toluene inhalation on behavior, monoamine metabolism and specific binding (3H-serotonin and 3Hnorepinephrine) of rat brain. Arch. Med. Res. 24 (1993) 169–176. 24. Jones, B.E. Arousal systems. Frontiers Biosci. 8 (2003) 438–451. 25. Datta, S., Patterson, E.H. and Spoley, E.E. Excitation of pedunculopontine tegmental NMDA receptors induces wakefulness and cortical activation in the rat. J. Neurosci. Res. 66 (2001) 109–116. 26. Maisuradze, L., Lortkipanidze, N., Eliozishvili, M., Oniani, N. and Oniani, T. A qualitative and quantitative assessment of the sleep–wakefulness cycle architecture in the postparadoxical sleep deprivation period. Sleep Research Online 5 (2003) 59–66.