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http://eprints.org/relation/isVersionOf http://eprints.iliauni.edu.ge/id/document/1059 http://eprints.org/relation/isVolatileVersionOf http://eprints.iliauni.edu.ge/id/document/1059 http://eprints.org/relation/issmallThumbnailVersionOf http://eprints.iliauni.edu.ge/id/document/1059 archive 87 disk0/00/00/03/02 2014-01-20 16:33:31 2015-04-16 08:41:46 2014-01-20 16:33:31 article show Zhvania Mzia G mzia_zhvania@iliauni.edu.ge Zhvania M pub QD ins10 public The rôle of secretion and membrane fusion in health and disease is profound. The pioneering discoveries by Jena and Rothman of a new cellular structure, the porosome, have essentially explained this process. The elucidation of the porosome’s morphology, composition and functional reconstitution in lipid membranes explain how cellular products destined for secretion undergo maturation by shuttling between subcellular compartments via budding and fusion of transport vesicles. Finally packaged in membranous sacs called secretory vesicles, which fuse at specific plasma membrane locations, they expel their contents. These and some other aspects of the discoveries of these scientists are described. 2004 Journal of Biological Physics and Chemistry 4 Collegium Basilea & AMSI 43-45 TRUE ISSN 1512-0856