244 9 1761 1 5030 document 1761 Solomonia et al.-Neuroscience Letters.pdf application/pdf 3485f021921b8a0a2fefdef75e1d844e MD5 402228 2014-01-23 07:37:57 http://eprints.iliauni.edu.ge/244/1/Solomonia%20et%20al.-Neuroscience%20Letters.pdf 244 1 1 application/pdf text en public

Solomonia et al.-Neuroscience Letters.pdf

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http://eprints.org/relation/isVersionOf http://eprints.iliauni.edu.ge/id/document/1761 http://eprints.org/relation/isVolatileVersionOf http://eprints.iliauni.edu.ge/id/document/1761 http://eprints.org/relation/ismediumThumbnailVersionOf http://eprints.iliauni.edu.ge/id/document/1761 1771 2 5042 document 1771 small.jpg image/png 78c76a2ea51f30a7da2a5c15e3e7e949 MD5 1845 2014-01-23 07:39:40 http://eprints.iliauni.edu.ge/244/5/small.jpg 244 5 5 image/png other Thumbnails conversion from text to thumbnail_small ge public

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http://eprints.org/relation/isVersionOf http://eprints.iliauni.edu.ge/id/document/1761 http://eprints.org/relation/isVolatileVersionOf http://eprints.iliauni.edu.ge/id/document/1761 http://eprints.org/relation/issmallThumbnailVersionOf http://eprints.iliauni.edu.ge/id/document/1761 archive 27 disk0/00/00/02/44 2015-04-07 08:56:02 2016-06-30 12:23:33 2015-04-07 08:56:02 article show Solomonia Revaz revaz_solomonia@iliauni.edu.ge Mikautadze Eka Nozadze Maia Kutchiashvili Nino Lepsveridze Eka eka_lepsveridze@iliauni.edu.ge Kiguradze Tamar pub QP fac_med public Identification of the compounds preventing the biochemical changes underlying the epileptogenesis process is of great importance. We have previously shown that myo-inositol (MI) administration reduces kainic acid (KA) induced seizure scores. MI treatment effects on biochemical changes triggered by KA induced status epilepticus (SE) were investigated in the present study. After SE one group of rats was treated with saline, whereas the second group with MI. Control groups received either saline or MI administration. Changes in the amounts of following proteins were studied in the hippocampus and neocortex of rats: GLUR1 subunit of glutamate receptors, calcium/calmodulin-dependent protein kinase II (CaMKII), and heat shock protein 90. No changes were found 28-30h after experiments. However on 28th day of experiment the amounts of GLUR1 and CaMKII were strongly reduced in the hippocampus of KA treated animals but MI significantly halted this reduction. Obtained results indicate anti-epileptogenic features of MI on biochemical level. 2010 published Neurosci Lett. 468 3 277-281 TRUE http://www.sciencedirect.com/science/article/pii/S0304394009014785