Effect of Myo-inositol treatment on hippocampal cell loss triggered by kainic acid induced status epilepticus: light and electron microscope studies

225 11 893 1 2735 document 893 CEMN-S-13-00028.pdf application/pdf 2b440a791e4d86934e1f6703b6d5a15e MD5 2858641 2014-01-20 07:31:31 http://eprints.iliauni.edu.ge/225/1/CEMN-S-13-00028.pdf 225 1 1 application/pdf text ge public

CEMN-S-13-00028.pdf

903 2 2759 document 903 lightbox.jpg image/png a1ff3a3564f8accffed67f1fd368a1ca MD5 41985 2014-01-20 07:51:36 http://eprints.iliauni.edu.ge/225/3/lightbox.jpg 225 3 3 image/png other Thumbnails conversion from text to thumbnail_lightbox ge public

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http://eprints.org/relation/isVersionOf http://eprints.iliauni.edu.ge/id/document/893 http://eprints.org/relation/isVolatileVersionOf http://eprints.iliauni.edu.ge/id/document/893 http://eprints.org/relation/issmallThumbnailVersionOf http://eprints.iliauni.edu.ge/id/document/893 archive 87 disk0/00/00/02/25 2014-01-20 08:45:33 2016-06-30 12:22:51 2014-01-20 08:45:33 article show Kotaria Nato N_KOTARIA@YAHOO.COM Zhvania Mzia G mzia_zhvania@iliauni.edu.ge Kiladze Maia maia.kiladze1@iliauni.edu.ge Japaridze Nadezhda nadia_japaridze@yahoo.com Solomonia Revaz revaz_solomonia@iliauni.edu.ge Bikashvili Tamar takobikashvili@yahoo.com Bolkvadze Tamar t_bolkvadze@yahoo.com Solomonia Revaz O Kiladze Maia, PhD student Effect of Myo-inositol treatment on hippocampal cell loss triggered by kainic acid induced status epilepticus: light and electron microscope studies pub QP ins10 public Recently it was shown that myo-inositol pretreatment attenuates the seizure severity and several biochemical changes provoked by experimentally induced status epilepticus. However it remains unknown whether such properties of myo-inositol influence the structure of epileptic brain. In the present light and electron microscopic research we elucidate if pretreatment with myo-inositol has positive effect on hippocampal cell loss and cell damage provoked by kainic acid induced status epilepticus. Adult male Wistar rats were treated with (i) saline, (ii) saline + kainic acid, (iii) myo-inositol + kainic acid. The cell loss was assessed 2, 14 and 30 days after treatment in radial, oriental and pyramidal cell layers of CA1 and CA3. The ultrastructural alterations were described in CA1, 14 days after treatment. The cytoprotective effect of myo-inositol was shown. Itt was most strongly expressed in pyramidal layer of CA1 and radial and oriental layers of CA3, in less degree - in almost all other layers of both areas. Electron-microscopic studies also indicate that in comparing with rats treated with kainic acid, the ultrastructure of CA1 of animals pretreated with myo-inostiol is more preserved. Such data give us the possibility to share recent opinion that in addition to other functions, myo-inositol possesses antiepileptogenic properties. 2013 Cellular and Molecular Neurobiology 33 5 Springer 659-671 TRUE 0272-4340